Review

human kirc cell line 786-o (Procell Inc)

About

News

Press Release

Team

Advisors

Partners

Contact

Bioz Stars

Bioz vStars

Buy from Supplier

Structured Review

Procell Inc human kirc cell line 786-o
Human Kirc Cell Line 786 O, supplied by Procell Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+kirc+cell+line+786-o/human+kirc+cell+line+786+o/pm32444962-41-1-22
Average 90 stars, based on 1 article reviews

human kirc cell line 786-o - by Bioz Stars, 2026-09

90/100 stars

Images

other:

Article Title: Comprehensive analysis of the HOXA gene family identifies HOXA13 as a novel oncogenic gene in kidney renal clear cell carcinoma.
Article Snippet: Objectives Kidney renal clear cell carcinoma (KIRC) is one of the most common lethal cancers in the human urogenital system.. As members of the Homeobox (HOX) family, Homeobox-A (HOXA) cluster genes have been reported to be involved in the development of many cancer types.. However, the expression and clinical significance of HOXA genes in KIRC remain largely unknown.

Image Search Results

Dapagliflozin sensitizes renal cell carcinoma to sunitinib therapy, alleviating sunitinib resistance. A Schematic representation of the experimental design for establishing a model of sunitinib-induced cardiotoxicity in nude mice. B , C Representative images of tumors derived from 786-O cells and the quantitative results of the weights of tumors derived from 786-O cells ( n = 22). D 786-O and 769-P cell administration with dapagliflozin were treated with a serial dose of sunitinib for 24 h and the IC50 values of sunitinib in each group were measured using the CCK-8 assay. E The graphical representation of the sunitinib resistance model establishment. F Representative images and quantitative results of EDU staining ( n = 6). G 786-O-R cell administration with dapagliflozin were treated with a serial dose of sunitinib for 24 h and the IC50 values of sunitinib in each group were measured using the CCK-8 assay. All data are expressed as the mean ± S.D., and analyzed using one-way ANOVA followed by Tukey post hoc test. * P < 0.05, ** P < 0.01 versus the matched group

Journal: BMC Medicine

Article Title: Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib

doi: 10.1186/s12916-025-04576-z

Figure Lengend Snippet: Dapagliflozin sensitizes renal cell carcinoma to sunitinib therapy, alleviating sunitinib resistance. A Schematic representation of the experimental design for establishing a model of sunitinib-induced cardiotoxicity in nude mice. B , C Representative images of tumors derived from 786-O cells and the quantitative results of the weights of tumors derived from 786-O cells ( n = 22). D 786-O and 769-P cell administration with dapagliflozin were treated with a serial dose of sunitinib for 24 h and the IC50 values of sunitinib in each group were measured using the CCK-8 assay. E The graphical representation of the sunitinib resistance model establishment. F Representative images and quantitative results of EDU staining ( n = 6). G 786-O-R cell administration with dapagliflozin were treated with a serial dose of sunitinib for 24 h and the IC50 values of sunitinib in each group were measured using the CCK-8 assay. All data are expressed as the mean ± S.D., and analyzed using one-way ANOVA followed by Tukey post hoc test. * P < 0.05, ** P < 0.01 versus the matched group

Article Snippet: The human KIRC cell lines 786-O and 769-P were procured from the American Type Culture Collection (ATCC) and maintained in RPMI 1640 medium (Cytiva, Logan, UT, USA) supplemented with 10% FBS.

Techniques: Derivative Assay, CCK-8 Assay, Staining

Validating MMP2, MMP9, MMP12, and MMP16 promoter methylation levels on clinical KIRC samples and cell lines (786-O and A-498) paired with controls via targeted bisulfite-seq analysis. (A) Beta values based promoter methylation based validation of MMP2, MMP9, MMP12, and MMP16 in clinical KIRC samples as compare to controls. * p < 0.05; (B) Beta values based promoter methylation based validation of MMP2, MMP9, MMP12, and MMP16 in KIRC cell lines as compare to control cell line.

Journal: Oncology Research

Article Title: Identifying and validating MMP family members (MMP2, MMP9, MMP12, and MMP16) as therapeutic targets and biomarkers in kidney renal clear cell carcinoma (KIRC)

doi: 10.32604/or.2023.042925

Figure Lengend Snippet: Validating MMP2, MMP9, MMP12, and MMP16 promoter methylation levels on clinical KIRC samples and cell lines (786-O and A-498) paired with controls via targeted bisulfite-seq analysis. (A) Beta values based promoter methylation based validation of MMP2, MMP9, MMP12, and MMP16 in clinical KIRC samples as compare to controls. * p < 0.05; (B) Beta values based promoter methylation based validation of MMP2, MMP9, MMP12, and MMP16 in KIRC cell lines as compare to control cell line.

Article Snippet: Cell lines: Human KIRC cell lines (786-O and A-498), and normal renal tubular epithelial cell line (HK-2) were purchased from the American Type Culture Collection (ATCC, USA) and cultivated in accordance with the manufacturer’s instructions.

Techniques: Methylation, Bisulfite Sequencing, Biomarker Discovery, Control

Oncogenic role of RIPK2 in human kidney cancer. ( A ) Change of RIPK2 mRNA expression between tumor samples and normal samples from TCGA KIRC studies. ( B ) Dot plot showing the positive correlation between RIPK2 copy number values defined by GISTIC2 approach and mRNA expression values quantified by FPKM. ( C ) Dot plot showing the correlation between RIPK2 methylation values defined by HM450 approach and mRNA expression values quantified by FPKM. ( D ) Kaplan–Meier survival curve comparing the high and low expression value of RIPK2 (determined by the mean or quantile value) for the TCGA KIRC patient cohort. Statistical significance was determined by one-way ANOVA and the log-rank test.

Journal: Aging (Albany NY)

Article Title: RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma

doi: 10.18632/aging.202808

Figure Lengend Snippet: Oncogenic role of RIPK2 in human kidney cancer. ( A ) Change of RIPK2 mRNA expression between tumor samples and normal samples from TCGA KIRC studies. ( B ) Dot plot showing the positive correlation between RIPK2 copy number values defined by GISTIC2 approach and mRNA expression values quantified by FPKM. ( C ) Dot plot showing the correlation between RIPK2 methylation values defined by HM450 approach and mRNA expression values quantified by FPKM. ( D ) Kaplan–Meier survival curve comparing the high and low expression value of RIPK2 (determined by the mean or quantile value) for the TCGA KIRC patient cohort. Statistical significance was determined by one-way ANOVA and the log-rank test.

Article Snippet: Human KIRC cell line 786-O cells (CRL-1932TM) and HEK293T cells (CRL-11268TM) were obtained from ATCC.

Techniques: Expressing, Methylation

Identification of differentially upregulated expressed genes. ( A ) Volcano plot of mRNA expression changes between KIRC samples harboring RIPK2 high- and low- expression value. The x-axis specifies the log2 fold-changes (FC) and the y-axis specifies the negative logarithm to the base 10 of the adjusted p-values. Gray vertical and horizontal dashed lines reflect the filtering criteria. Red and green dots represent genes expressed at significantly higher or lower levels, respectively. ( B ) Top 10 Gene ontology enrichment terms for up-regulated (top) and down-regulated (bottom) genes, respectively.

Journal: Aging (Albany NY)

Article Title: RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma

doi: 10.18632/aging.202808

Figure Lengend Snippet: Identification of differentially upregulated expressed genes. ( A ) Volcano plot of mRNA expression changes between KIRC samples harboring RIPK2 high- and low- expression value. The x-axis specifies the log2 fold-changes (FC) and the y-axis specifies the negative logarithm to the base 10 of the adjusted p-values. Gray vertical and horizontal dashed lines reflect the filtering criteria. Red and green dots represent genes expressed at significantly higher or lower levels, respectively. ( B ) Top 10 Gene ontology enrichment terms for up-regulated (top) and down-regulated (bottom) genes, respectively.

Article Snippet: Human KIRC cell line 786-O cells (CRL-1932TM) and HEK293T cells (CRL-11268TM) were obtained from ATCC.

Techniques: Expressing

Gene set enrichment analysis between RIPK2 high- and low- expression samples. GSEA comparing gene-expression signatures of TCGA KIRC tumors with the RIPK2 high- and low-expression by using hallmark gene sets. GSEA positive result table ( A ) showing all the significant enrichment terms of the hallmark keg pathway gene sets from MSigDB, and GSEA negative result table ( B ) showing significant enrichment terms of the KEGG pathway gene sets from MSigDB.

Journal: Aging (Albany NY)

Article Title: RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma

doi: 10.18632/aging.202808

Figure Lengend Snippet: Gene set enrichment analysis between RIPK2 high- and low- expression samples. GSEA comparing gene-expression signatures of TCGA KIRC tumors with the RIPK2 high- and low-expression by using hallmark gene sets. GSEA positive result table ( A ) showing all the significant enrichment terms of the hallmark keg pathway gene sets from MSigDB, and GSEA negative result table ( B ) showing significant enrichment terms of the KEGG pathway gene sets from MSigDB.

Article Snippet: Human KIRC cell line 786-O cells (CRL-1932TM) and HEK293T cells (CRL-11268TM) were obtained from ATCC.

Techniques: Expressing, Gene Expression

Immune signaling interactions and network analysis. ( A ) The table showed the significant signaling networks actively compared between the RIPK2 high-, and low-expression samples by using Ingenuity Pathway Analysis (IPA) database. ( B ) The highest-ranked immunological signal pathway network revealed by IPA. Proteins indicated in red were up-regulated in RIPK2-high KIRC samples and the intensity of red means the foldchange. The shapes are indicative of the molecular class (i.e. protein family). Lines connecting the molecules indicate molecular relationships. In detail, dashed lines indicate indirect interactions, and solid lines indicate direct interactions. The style of the arrows indicates specific molecular relationships and the directionality of the interaction ( A acts on B ).

Journal: Aging (Albany NY)

Article Title: RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma

doi: 10.18632/aging.202808

Figure Lengend Snippet: Immune signaling interactions and network analysis. ( A ) The table showed the significant signaling networks actively compared between the RIPK2 high-, and low-expression samples by using Ingenuity Pathway Analysis (IPA) database. ( B ) The highest-ranked immunological signal pathway network revealed by IPA. Proteins indicated in red were up-regulated in RIPK2-high KIRC samples and the intensity of red means the foldchange. The shapes are indicative of the molecular class (i.e. protein family). Lines connecting the molecules indicate molecular relationships. In detail, dashed lines indicate indirect interactions, and solid lines indicate direct interactions. The style of the arrows indicates specific molecular relationships and the directionality of the interaction ( A acts on B ).

Article Snippet: Human KIRC cell line 786-O cells (CRL-1932TM) and HEK293T cells (CRL-11268TM) were obtained from ATCC.

Techniques: Expressing

SETD2 and BAP1 genomic alterations are selectively enriched in RIPK2 -high expression samples. ( A ) cBioPortal OncoPrint plot showing the distribution of VHL, PBRM1, CDKN2A, SETD2, BAP1, and MTOR genomic alterations rate in the TCGA KIRC dataset. ( B ) Bar graphs showing the percentage of TCGA KIRC samples with genomic alterations in SETD2 and BAP1 by different RIPK2 expression groups.

Journal: Aging (Albany NY)

Article Title: RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma

doi: 10.18632/aging.202808

Figure Lengend Snippet: SETD2 and BAP1 genomic alterations are selectively enriched in RIPK2 -high expression samples. ( A ) cBioPortal OncoPrint plot showing the distribution of VHL, PBRM1, CDKN2A, SETD2, BAP1, and MTOR genomic alterations rate in the TCGA KIRC dataset. ( B ) Bar graphs showing the percentage of TCGA KIRC samples with genomic alterations in SETD2 and BAP1 by different RIPK2 expression groups.

Article Snippet: Human KIRC cell line 786-O cells (CRL-1932TM) and HEK293T cells (CRL-11268TM) were obtained from ATCC.

Techniques: Expressing

$The difference in clinical characteristics between RIPK2 high- and low- expression samples. ( A ) Distribution of M0 and MX samples among different RIPK2 expression subtypes of KIRC from the TCGA patient cohort and functional modules activation analysis by IPA based on up-regulated genes in RIPK2 -high samples. ( B ) Distribution of tumor stages among different RIPK2 expression subtypes. ( C ) The distribution plot of the patient’s somatic mutation count (left) and the patient’s fraction of copy number altered (right) among KIRC patients between RIPK2 high- and low- expression samples.$

Journal: Aging (Albany NY)

Article Title: RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma

doi: 10.18632/aging.202808

Figure Lengend Snippet: The difference in clinical characteristics between RIPK2 high- and low- expression samples. ( A ) Distribution of M0 and MX samples among different RIPK2 expression subtypes of KIRC from the TCGA patient cohort and functional modules activation analysis by IPA based on up-regulated genes in RIPK2 -high samples. ( B ) Distribution of tumor stages among different RIPK2 expression subtypes. ( C ) The distribution plot of the patient’s somatic mutation count (left) and the patient’s fraction of copy number altered (right) among KIRC patients between RIPK2 high- and low- expression samples.

Article Snippet: Human KIRC cell line 786-O cells (CRL-1932TM) and HEK293T cells (CRL-11268TM) were obtained from ATCC.

Techniques: Expressing, Functional Assay, Activation Assay, Mutagenesis

Review

human kirc cell line 786-o (Procell Inc)

Structured Review

Images

Related Articles

other:

Similar Products

Image Search Results